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Wissenschaft und Forschung in der Herzchirurgie

Publikationen:

Zahlreiche Veröffentlichungen entstanden in enger interdisziplinärer Zusammenarbeit mit Kollegen anderer Fachabteilungen und Kliniken sowie dem Max-Planck-Institut in Bad Nauheim. Insbesondere Studien zu Herzschrittmacher und Defibrillatoren wurden in enger Zusammenarbeit mit den Kardiologen der Herzschrittmacher- und Defibrillatorambulanz sowie den Kollegen der EPU-Abteilung durchgeführt. Daher sind in der folgenden Liste die Kollegen der Herzchirurgie fett unterlegt.

Klinische und experimentelle Forschung der Abteilung für Herzchirurgie

2010

Burger H, Schwarz T, Ehrlich W, Sperzel J, Kloevekorn WP, Ziegelhoeffer T: New generation of transvenous left ventricular leads - first experience with implantation of multipolar left ventricular leads. [in Veröffentlichung]

Burger H, Schwarz T, Ehrlich W, Kloevekorn WP, Ziegelhoeffer T: Endurance and performance of two different concepts for left ventricular stimulation with bipolarepicardial leads in long-term follow-up. Feb 2010 (Stuttgart) [in Veröffentlichung]

Schönburg M, Nedelmann M, Walberer M, Dönges S, Ritschel N, Bachmann G, Stolz E, Urbanek S, Ziegelhoeffer T, Szalay Z, Urbanek P, Gerriets T: A rat model for cerebral air microembolisation. Feb 2010 (Stuttgart) [in Veröffentlichung]

2009

Heidt MC, Sedding D, Stracke SK, Stadlbauer T, Boening A, Vogt PR, Schönburg M: Measurement of myocardial oxygen tension: a valid and sensitive method in the investigation of transmyocardial laser revascularization in an acute ischemia model. Thorac Cardiovasc Surg. 2009 Mar;57(2):79-84. Epub 2009 Feb 24.

Burger H, Schwarz T, Ehrlich W, Sperzel J, Klövekorn WP, Ziegelhöffer T: Haltbarkeit und Performance von zwei unterschiedlichen Konzepten zur linksventrikulären Stimulation mit bipolaren epikardialen Sonden im Langzeit-Follow-up. Clin Res Cardiol 2009 Okt; 98 Suppl 2

Gerriets T, Walberer M, Ritschel N, Tschernatsch M, Mueller C, Bachmann G, Schoenburg M, Kaps M, Nedelmann M: Edema formation in the hyper acute phase of ischemic stroke. J Neurosurg 2009 Nov;111(5):1036-42

Aulbach V, Georg S, Jung M, Schwarz T, Burger H, Ehrlich W, Erkapic D, Pajitnev D, Kuniss M, Neumann T, Zaltsberg S, Pitschner HF, Sperzel J, Hamm CW: Prävalenz von Blutungskomplikationen bei Schrittmacher- und Defibrillator-implantationen unter aktuellen Formen der Thrombozyten-aggregationshemmung und therapeutischen Antikoagulation. Clin Res Cardiol 2009 Apr; 98- Suppl 1

Gerriets T, Schwarz N, Sammer G, Baehr J, Stolz E, Kaps M, Kloevekorn WP, Bachmann G, Schönburg M: Protecting the brain from gaseous and solid microemboli during coronary artery bypass grafting: a randomised controlled trial. Eur heart journal 2009 Jun 18

2008

Schönburg M, Ziegelhoeffer T, Weinbrenner F, Bechtel M, Detter C, Krabatsch T, Osswald B, Riess FC, Scholz F, Stamm C, Sievers HH, Bartels C: Preexisting atrial fibrillation as predictor for late-time mortality in patients with end-stage renal disease undergoing cardiac surgery - a multicenter study. Thorac Cardiovasc Surg 2008;56(3):128-132.

Bechtel M, Detter C, Fischlein T, Krabatsch T, Osswald BR, Rieß FC, Scholz F, Schönburg M, Stamm C, Sievers HH, Bartels C, for the German Cardiac Surgery in ESRD-Patients Study-Group: Cardiac Surgery in Patients on Dialysis: Decreased 30-Day Mortality, Unchanged Overall Survival; Ann Thorac Surg. 2008 Jan;85(1):147-53

Brueck M, Bandorski D, Kramer W, Schoenburg M, von Gerlach S, Tillmanns H: Aortic Valve Stenosis due to Alkaptonuria J Heart Valve Dis Vol. 17. No. 1 January 2008

Hein S, Kostin S, Schaper J: mRNA cargo no longer on time. Am J Physiol Heart Circ Physiol 2008 Mar;294(3):H1130-2.

Polyakova V, Miyagawa S, Szalay Z, Risteli J, Kostin S: Atrial extracellular matrix remodelling in patients with atrial fibrillation. J Cell Mol Med 2008 Jan-Feb;12(1):189-208.

2007

Vogt J, Schwarz T, Gras D, Sperzel J, Ritter P, de Voogt W, Cebron JP, Seifert M, Tockman B, Schubert B, Johnson E, Doelger A, Pochet T, Mouton E, Butter C: The use of telescoping guide catheters for coronary sinus cannulation and sub-selecting tributaries in left ventricular lead placement. J Interv Card Electrophysiol. 2007 Jun; 19(1):61-8. Epub 2007 Jul 7

Kennergren C, Bucknall CA, Butter C, Charles R, Fuhrer J, Grosfeld M, Tavernier R, Morgado TB, Mortensen P, Paul V, Richter P, Schwarz T, Wellens F: Laser-assisted lead extraction: the European experience. Europace 2007 Aug;918:651-6

Limbourg A, Ploom M, Elligsen D, Sorensen I, Ziegelhoeffer T, Gossler A, Drexler H, Limbourg FP: Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res 2007;100(3):363-371.

Walberer M, Blaes F, Stolz E, Mueller C, Schoenburg M, Tschernatsch M, Bachmann G, Gerriets T: MIDLINE-SHIFT CORRESPONDS TO THE AMOUNT OF BRAIN OEDEMA EARLY AFTER HEMISPHERIC STROKE - An MRI-study in rats; J Neurosurg Anesth 2007 Apr;19(2):105-10

Brueck M, Kramer W, Vogt P, Steinert N, Roth P, Gorlach G, Schonburg M, Heidt MC. Antiplatelet therapy early after bioprosthetic aortic valve replacement is unnecessary in patients without thromboembolic risk factors, Eur J Cardiothorac Surg 2007; Volume 31, Issue 4, Pages 571-758

Ogutu P, Szalay Z, Roth M, Schönburg M, Kraus B, Klövekorn WP: Thrombectomy for prosthetic heart valve obstruction. J Card Surg 2007 May-Jun;22(3):218.

2006

Schonburg M, Ziegelhoeffer T, Kraus B, Muhling A, Heidt M, Taborski U, Gerriets T, Roth M, Hein S, Urbanek S, Klovekorn WP: Reduction of gaseous microembolism during aortic valve replacement using a dynamic bubble trap. Gen Physiol Biophys 2006;25(2):207-214.

Schoenburg M, Baer J, Schwarz N, Stolz E, Kaps M, Bachmann G, Gerriets T. EmboDop: insufficient automatic microemboli identification. Stroke 2006 Feb;37(2):342-3. Epub 2006 Jan 5

Helisch A, Wagner S, Khan N, Drinane M, Wolfram S, Heil M, Ziegelhoeffer T, Brandt U, Pearlman JD, Swartz HM, Schaper W: Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler Thromb Vasc Biol 2006;26(3):520-526.

Hein S, Kostin S, Schaper J: Adult rat cardiac myocytes in culture: 'Second-floor' cells and coculture experiments. Exp Clin Cardiol 2006 Fall;11(3):175-82.

Jovin IS, Taborski U, Szalay Z, Friedel A, Segieth I, Jovin A, Heidinger K, Schreiner K, Frass O, Klövekorn WP, Müller-Berghaus G: Trapidil decreases the aggregation of platelets from heart transplant recipients ex vivo. Transplant Proc 2006 Jun;38(5):1523-5.

2005

Kubin T, Tomars M, Fach C, Hein S, Bramlage P, Shim GJ, Scholz D, Kostin S, Zimmermann R, Elsässer A, Schaper W, Schaper J: Transforming growth factor-beta1 downregulates beating frequency and remodeling of cultured rat adult cardiomyocytes.
Cell Tissue Res 2005 Jul;321(1):57-66.

Boriani G, Biffi M, Schwarz T, Dong Y, Koenig A, Temporin S, Meyer S, Sperzel J: Evaluation of fusion beat detection with a new ventricular automatic capture algorithm in ICDs. Pacing Clin Electrophysiol. 2005 Jan; 28 Suppl 1:S263-6

Heidt MC, Schonburg M, Vogt PR; Contrast echocardiography: a valid and sensitive imaging method in the investigation of transmyocardial laser-revascularization in an acute ischemia model. Thorac Cardiovasc Surg. 2005 Dec;53(6):346-51

Lemke P, Roth M, Szalay Z, Klövekorn WP, Schönburg M: Non-aneurysmal inflammation of the aorta in combination with aortic valve disease. Thorac Cardiovasc Surg 2005 Apr;53(2):127-9.

2004

Wei-jun C, Scholz D, Ziegelhoeffer T, Schaper J: Structural remodeling during growth of collateral vessels. In: Schaper W, Schaper J: Arteriogenesis, Kluwer Academic Publishers Boston, Dordrecht, London, 2004, pp. 21-54.

Wagner, S, Helisch A, Ziegelhoeffer T: Magnetic resonance imaging. In: Schaper W, Schaper J: Arteriogenesis, Kluwer Academic Publishers Boston, Dordrecht, London, 2004, pp. 55-72.

Schaper W, Pipp F, Scholz D, Boehm S, Deindl E, Barancik M, Eitenmueller I, Ziegelhoeffer T, Kluge A, Schmitz-Rixen T: Physical forces and their translation into molecular mechanisms. In: Schaper W, Schaper J: Arteriogenesis, Kluwer Academic Publishers Boston, Dordrecht, London, 2004, pp. 73-114.

Ziegelhoeffer T, Kostin S, Fernandez B, Heil M, Schaper W: Bone marrow derived cells. In: Schaper W, Schaper J: Arteriogenesis, Kluwer Academic Publishers Boston, Dordrecht, London, 2004, pp. 159-172.

Polyakova V, Hein S, Kostin S, Ziegelhoeffer T, Schaper J: Matrix metalloproteinases and their tissue inhibitors in pressure-overloaded human myocardium during heart failure progression. J Am Col Cardiol 2004; 19;44(8):1609-1618.

Huss R, Heil M, Moosmann S, Ziegelhoeffer T, Sagebiel S, Seliger C, Kinston S, Gottgens B: Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL+ multipotent adult progenitor cell (MAP-C) clones from peripheral blood. J Vasc Res 2004;41:422-431.

Heil M, Ziegelhoeffer T, Wagner S, Fernandez B, Helisch A, Martin S, Tribulova S, Kuziel WA, Bachmann G, Schaper W: Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2. Circ Res 2004;94(5):671-677.

Heil M, Ziegelhoeffer T, Mees B, Schaper W: A different outlook on the role of bone marrow stem cells in vascular growth: bone marrow delivers software not hardware. Circ Res 2004;94(5):573-574.

Ziegelhoeffer T, Fernandez B, Kostin S, Heil M, Voswinckel R, Helisch A, Schaper W: Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ Res 2004;94(2):230-238.

Wagner S, Helisch A, Ziegelhoeffer T, Bachmann G, Schaper W: Magnetic resonance angiography of collateral vessels in a murine femoral artery ligation model. NMR Biomed 2004,17(1):21-27.

Kostin S, Dammer S, Hein S, Klovekorn WP, Bauer EP, Schaper J: Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis. Cardiovasc Res 2004 May 1;62(2):426-36.

Dill T, Breidenbach C, John A, Brandt RR, Ekinci O, Szalay Z, Bauer EP, Ricken W, Bachmann G, Hamm CW: Pre- and postoperative assessment of left ventricular function by magnetic resonance imaging and 2-D-echocardiography in patients undergoing left ventricular aneurysmectomy. Thorac Cardiovasc Surg 2004 Oct;52(5):274-9.

Szalay ZA, Skwara W, Klövekorn WP, Brunner-La Rocca HP, Knez I, Graves K, Vogt PR, Bauer EP: Predictors of failure to cure atrial fibrillation with the mini-maze operation. J Card Surg 2004 Jan-Feb;19(1):1-6.

Szalay ZA, Civelek A, Dill T, Klövekorn WP, Kilb I, Bauer EP: Long-term follow-up after the mini-maze procedure. Ann Thorac Surg 2004 Apr;77(4):1277-81.

Kluge A, Rominger M, Schönburg M, Bachmann G: Indirect MR venography: contrast medium protocols, postprocessing and combination in diagnosing pulmonary emboli with MRI. Rofo 2004 Jul;176(7):976-84.

2003

Carlsson J, Schulte B, Erdogan A, Sperzel J, Güttler N, Schwarz T, Pitschner HF, Neuzner J: Prospective randomized comparison of two defibrillation safety margins in unipolar, active pectoral defibrillator therapy. Pacing Clin Electrophysiol. 2003 Feb; 26(2 Pt 1):613-8.

Sperzel J, Pitschner HF, Schwarz T, König A, Zhu Q, Neuzner J: Automatic capture verification in ICD lead systems using intracardiac ventricular evoked response and reduced coupling capacitance. Europace. 2003 Jan; 5(1):83-9.

Kostin S, Pool L, Elsässer A, Hein S, Drexler HC, Arnon E, Hayakawa Y, Zimmermann R, Bauer E, Klövekorn WP, Schaper J: Myocytes die by multiple mechanisms in failing human hearts. Circ Res 2003 Apr 18;92(7):715-24.

Gorlach G, Sroka J, Heidt M, Knez I, Sablotzki A, Schonburg M, Akinturk H, Roth P, Wozniak G, Vogt PR. Intracellular adhesion molecule-1 in patients developing pulmonary insufficiency after cardiopulmonary bypass. Thorac Cardiovasc Surg. 2003 Jun;51(3):138-41

Vogt PR, Lutz HJ, Akintürk HI, Roth P, Schönburg M, Menon AK, Varga MS, Babin-Ebell J and Heidt M: Prevention of Postischemic Tissue Injury by Controlled Reperfusion: A Preliminary Study: Int J Angiol 2003, 12 (3)

Braun-Dullaeus RC, Ziegler A, Bohle RM, Bauer E, Hein S, Tillmanns H, Haberbosch W:
Quantification of the cell-cycle inhibitors p27(Kip1) and p21(Cip1) in human atherectomy specimens: primary stenosis versus restenosis. J Lab Clin Med 2003 Mar;141(3):179-89.

Kostin S, Rieger M, Dammer S, Hein S, Richter M, Klövekorn WP, Bauer EP, Schaper J: Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem 2003 Jan;242(1-2):135-44.

Kubin T, Vogel S, Wetzel J, Hein S, Pipp F, Herold J, Heil M, Kampmann A, Hehlgans S, von der Ahe D, Schaper W, Zimmermann R: Porcine aortic endothelial cells show little effects on smooth muscle cells but are potent stimulators of cardiomyocyte growth. Mol Cell Biochem 2003 Jan;242(1-2):39-45.

Hein S, Arnon E, Kostin S, Schönburg M, Elsässer A, Polyakova V, Bauer EP, Klövekorn WP, Schaper J: Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 2003 Feb 25;107(7):984-91.

Schoenburg M, Kraus B, Muehling A, Taborski U, Hofmann H, Erhardt G, Hein S, Roth M, Vogt PR, Karliczek GF, Kloevekorn WP: The dynamic air bubble trap reduces cerebral microembolism during cardiopulmonary bypass. J Thorac Cardiovasc Surg 2003 Nov;126(5):1455-60.

Civelek A, Szalay Z, Roth M, Arnold R, Klövekorn WP, Vogt PR, Bauer EP: Post-mitral valve repair systolic anterior motion produced by non-obstructive septal bulge. Eur J Cardiothorac Surg 2003 Dec;24(6):857-61.

Civelek A, Roth M, Lemke P, Klövekorn WP, Bauer EP: Leukocyte-depleted secondary blood cardioplegia attenuates reperfusion injury after myocardial ischemia. Thorac Cardiovasc Surg 2003 Oct;51(5):249-54.

Lemke P, Civelek A, Brandt R, Roth M: Accessory mitral valve tissue associated with situs inversus in an elderly patient. Eur J Cardiothorac Surg 2003 Jun;23(6):1071-3.

Szalay ZA, Civelek A, Hohe S, Brunner-LaRocca HP, Klövekorn WP, Knez I, Vogt PR, Bauer EP: Mitral annuloplasty in patients with ischemic versus dilated cardiomyopathy. Eur J Cardiothorac Surg 2003 Apr;23(4):567-72.

Taborski U, Urbanek P, Erhardt G, Schönburg M, Basser S, Wohlgemuth L, Heidinger K, Klövekorn WP: In vitro biocompatibility evaluation of the dynamic bubble trap. Artif Organs 2003 Aug;27(8):736-43.

Jovin IS, Stelzig G, Strelitz JC, Taborski U, Jovin A, Heidinger K, Klövekorn WP, Müller-Berghaus G: Post-operative course of coronary artery bypass surgery patients who pre-donate autologous blood. Int J Cardiol 2003 Dec;92(2-3):235-9.

2002

Hein S, Elsässer A, Kostin S, Zimmermann R, Schaper J: Functional disturbances due to structural remodeling in the failing human heart. Arch Mal Coeur Vaiss 2002 Sep;95(9):815-20. Review.

Schaper J, Kostin S, Hein S, Elsässer A, Arnon E, Zimmermann R: Structural remodelling in heart failure. Exp Clin Cardiol 2002 Fall;7(2-3):64-8.

Hein S, Gaasch WH, Schaper J: Giant molecule titin and myocardial stiffness. Circulation 2002 Sep 10;106(11):1302-4.

Hein S, Schaper J: Weakness of a giant: mutations of the sarcomeric protein titin. Trends Mol Med 2002 Jul;8(7):311-3.

Kostin S, Klein G, Szalay Z, Hein S, Bauer EP, Schaper J: Structural correlate of atrial fibrillation in human patients. Cardiovasc Res 2002 May;54(2):361-79.

Roth M, Lemke P, Schönburg M, Klövekorn WP, Bauer EP: Aneurysm formation after patch aortoplasty repair (Vossschulte): reoperation in adults with and without hypothermic circulatory arrest. Ann Thorac Surg 2002 Dec;74(6):2047-50.

Roth M, Lemke P, Bohle RM, Klövekorn WP, Bauer EP: Inflammatory aneurysm of the ascending thoracic aorta. J Thorac Cardiovasc Surg 2002 Apr;123(4):822-4.

2001

Fielitz J, Hein S, Mitrovic V, Pregla R, Zurbrügg HR, Warnecke C, Schaper J, Fleck E, Regitz-Zagrosek V: Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease. J Am Coll Cardiol 2001 Apr;37(5):1443-9.

Sperzel J, Neuzner J, Schwarz T, Zhu Q, König A, Kay GN: Reduction of pacing output coupling capacitance for sensing the evoked response. Pacing Clin Electrophysiol. 2001 Sep; 24(9 Pt 1):1377-82.

Schulte B, Sperzel J, Carlsson J, Schwarz T, Ehrlich W, Pitschner HF, Neuzner J: Dual-coil vs single-coil active pectoral implantable defibrillator lead systems: defibrillation energy requirements and probability of defibrillation success at multiples of the defibrillation energy requirements. Europace. 2001 Jul; 3(3):177-80.

Hein S, Schaper J: The extracellular matrix in normal and diseased myocardium.
J Nucl Cardiol 2001 Mar-Apr;8(2):188-96. Review.

Schönburg M, Urbanek P, Erhardt G, Kraus B, Taborski U, Mühling A, Hein S, Roth M, Tiedtke HJ, Klövekorn WP: Significant reduction of air microbubbles with the dynamic bubble trap during cardiopulmonary bypass. Perfusion 2001 Jan;16(1):19-25.

Lemke P, Roth M, Kraus B, Hohe S, Klövekorn WP, Bauer EP: Ruptured papillary muscle after mitral valve replacement with preservation of chordae tendineae. Ann Thorac Surg 2001 Oct;72(4):1384-6.

Roth M, Lemke P, Kraus B, Schönburg M, Brandt RR, Klövekorn WP, Bauer EP:Papillary muscle rupture after mitral valve replacement with preservation of subvalvular structures. Z Kardiol 2001 May;90(5):359-61.

Brandt RR, Neuzner J, Roth M, Bauer EP, Klövekorn WP, Hamm CW: Peripheral arterial embolism originating from a thrombus in the ascending aorta. Thorac Cardiovasc Surg 2001 Apr;49(2):122-4.

Roth M, Schönburg M, Kloevekorn WP, Bauer EP: Thrombotic formations within the aortic arch as source of embolization in patients with coagulopathia. Eur J Cardiothorac Surg 2001 Apr;19(4):534-6.

Roth M, Schönburg M, Klövekorn WP, Bauer EP: Inflammatory aneurysm of the ascending aorta. Eur J Cardiothorac Surg 2001 Feb;19(2):214.

Bauer EP, Szalay ZA, Brandt RR, Pitschner HF, Bachmann G, Brunner-La Rocca HP, Klövekorn WP: Predictors for atrial transport function after mini-maze operation. Ann Thorac Surg 2001 Oct;72(4):1251-4; discussion 1255.

2000

Holschermann H, Hilgendorff A, Kemkes-Matthes B, Schonburg M, Bauer EP, Tillmanns H, Haberbosch W: Simvastatin attenuates vascular hypercoagulability in cardiac transplant recipients. Transplantation 2000 May 15;69(9):1830-6

Neuzner J, Schwarz T, Sperzel J: Pacemaker automaticity. Am J Cardiol. 2000 Nov 2; 86(9A):104K-110K. Review.

Sperzel J, Carlsson J, Erdogan A, Ehrlich W, Schulte B, Pitschner HF, Neuzner J: Recurrent syncope of unknown origin. Diagnosis with implantable "loop" recorders. Med Klin (Munich). 2000 Oct 15; 95(10):578-82.

Schulte B, Sperzel J, Schwarz T, Pitschner HF, Strupp G, Neuzner J: Detection of ventricular fibrillation in implantable defibrillators with automatic gain control amplifiers: effects of programming sensitivity. Europace. 2000 Apr; 2(2):160-2.

Sperzel J, Schulte B, Schwarz T, Ehrlich W, Neuzner J.
Herzschrittmacherther Elektrophysiol. 2000 Jan;11 Suppl 1:31-2. German.

Sperzel J, Ehrlich W, Carlsson J, Schwarz T, König A, Zhu Q, Neuzner J. Herzschrittmacherther Elektrophysiol. 2000 Jan;11 Suppl 1:55-6.

Sperzel J, Ehrlich W, Carlsson J, Schwarz T, König A, Zhu Q, Neuzner J. Herzschrittmacherther Elektrophysiol. 2000 Jan;11 Suppl 1:107-8.

Carlsson J, Schulte B, Sperzel J, Erdogan A, Röderich H, Schwarz T, Ehrlich W, Pitschner HF, Neuzner J. Herzschrittmacherther Elektrophysiol. 2000 Jan;11 Suppl 1:49-50.

Schonburg M, Urbanek P, Erhardt G, Taborski U, Plechinger H, Hein S, Roth M, Klövekorn WP: Air microbubbles reduction during cardiopulmonary bypass: a case study. J.Extra.Corpor.Technol. 2000; 32: 165-169

Kostin S, Hein S, Arnon E, Scholz D, Schaper J: The cytoskeleton and related proteins in the human failing heart. Heart Fail Rev 2000 Oct;5(3):271-80. Review.

Schönburg M, Urbanek P, Erhardt G, Taborski U, Plechinger H, Hein S, Roth M, Klövekorn WP: A dynamic bubble trap reduces microbubbles during cardiopulmonary bypass: a case study. J Extra Corpor Technol 2000 Sep;32(3):165-9.

Elsässer A, Decker E, Kostin S, Hein S, Skwara W, Müller KD, Greiber S, Schaper W, Klövekorn WP, Schaper J: A self-perpetuating vicious cycle of tissue damage in human hibernating myocardium. Mol Cell Biochem 2000 Oct;213(1-2):17-28.

Heling A, Zimmermann R, Kostin S, Maeno Y, Hein S, Devaux B, Bauer E, Klövekorn WP, Schlepper M, Schaper W, Schaper J: Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium. Circ Res 2000 Apr 28;86(8):846-53. Erratum in: Circ Res 2000 Jul 21;87(2):167.

Hein S, Kostin S, Heling A, Maeno Y, Schaper J: The role of the cytoskeleton in heart failure. Cardiovasc Res 2000 Jan 14;45(2):273-8. Review.

Roth M, Kraus B, Scheffold T, Reuthebuch O, Klövekorn WP, Bauer EP: The effect of leukocyte-depleted blood cardioplegia in patients with severe left ventricular dysfunction: a randomized, double-blind study. J Thorac Cardiovasc Surg 2000 Oct;120(4):642-50.

Roth M, Sprengel U, Haberbosch W, Kraus B, Klövekorn WP, Bauer EP: Symptomatic true aneurysm of a venous bypass with compression of the right atrium. Z Kardiol 2000 May; 89(5):418-22.

Ehrlich W, Skwara W, Klövekorn W, Roth M, Bauer EP: Do patients want minimally invasive aortic valve replacement? Eur J Cardiothorac Surg. 2000 Jun; 17(6):714-7.

Szalay ZA, Skwara W, Pitschner HF, Faude I, Klövekorn WP, Bauer EP: The maze operation--surgical therapy of chronic atrial fibrillation: modification to mini-maze operation.
Z Kardiol 2000; 89 Suppl 10:29-34. German.

Neumann T, Ehrlich W, Sperzel J, Kimmel A, Willems R, Klövekorn WP, Neuzner J.
Herzschrittmacherther Elektrophysiol 2000 Jan; 11 Suppl 1: 91-2.

1999

Kostin S, Hein S, Bauer EP, Schaper J. Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Circ Res 1999 Jul 23; 85(2):154-67.

Schulz O, Mitrovic V, Schönburg M, Thormann J: High dose enoximone to evaluate reversibility of pulmonary hypertension: Is there a diagnostic value of neurohormonal measurements? Am Heart J 1999;137:887-94

Neuzner J, Sperzel J, Pitschner HF, Schwarz T, Ehrlich W, Schulte B, Haberbosch W. Bipolar atrial sensing thresholds in sinus rhythm and atrial tachyarrhythmias. A comparative analysis in patients with DDDR pacemakers. Europace. 1999 Apr; 1(2):135-9.

Butter C, Auricchio A, Schwarz T, Fleck E, Schubert B, Hsu W, Michel U, Neuzner J: Clinical evaluation of a prototype passive fixation dual chamber single pass lead for dual chamber ICD systems. Pacing clin Electrophysiol 1999 Jan;22(1Pt2): 169-73

Neuzner J, Schwarz T, Sperzel J, Schulte B, Ehrlich W: Transvenöse Extranktionen defekter ICD-Elektrodensystemen: Zentrumserfahrung mit unterschiedlichen Methoden bei unterschiedlichen Elektrodenmodellen. Vortrag zur 65. Jahrestagung der DGK 1999 Mannheim

Schwarz T, Ehrlich W, Sperzel J, Neuzner J, Klövekorn WP, Bauer EP. Laser assisted removal of ICD leads: A efficient or risky Method? Thieme Stuttgart 1999

Urbánek P, Erhardt G, Taborski U, Schönburg M, Tiedtke HJ, Klövekorn WP: Dynamische Luftfalle- Methode zur Beseitigung von Luftmikrobläschen aus arteriellem Blut während extrakorporalen Zirkulation; Zeitschrift für Kardiotechnik 1999;8, 100-102

Kubin T, Ando H, Scholz D, Bramlage P, Kostin S, van Veen A, Heling A, Hein S, Fischer S, Breier A, Schaper J, Schaper W: Microvascular endothelial cells remodel cultured adult cardiomyocytes and increase their survival. Am J Physiol 1999 Jun; 276(6 Pt 2):H2179-87.

Roth M, Sprengel U, Kraus B, Klövekorn WP, Bauer EP: Symptomatic aneurysm of a saphenous vein graft with compression of the right atrium. Heart Surg Forum 1999; 2(4):338-40.

Reuthebuch O, Podzuweit T, Thomas S, Binz K, Roth M, Klövekorn WP, Bauer EP: Transmyocardial laser revascularisation has no beneficial effect on high energy phosphates and lactate content during acute myocardial ischaemia in pigs. Eur J Cardiothorac Surg 1999 Aug; 16(2):144-9.

Reuthebuch O, Roth M, Skwara W, Klövekorn WP, Bauer EP: Cardioscopy: potential applications and benefit in cardiac surgery. Eur J Cardiothorac Surg 1999 Jun; 15(6):824-9.

Roth M, Reuthebuch OT, Klövekorn WP, Bauer EP: Repair of an aneurysm of the pulmonary trunk in a 65-year-old patient. Ann Thorac Surg 1999 Jan; 67(1):244-6.

Szalay ZA, Skwara W, Pitschner HF, Faude I, Klövekorn WP, Bauer EP: Midterm results after the Mini-Maze procedure. Eur J Cardiothorac Surg 1999 Sep; 16(3):306-11.

1998

Schulte B, Schwarz T, Sperzel J, Pitschner HF, Klövekorn WP, Neuzner J: Dysfunctions of transvenous cardioverter/defibrillator electrode systems: clinical significance of system integrated diagnosis and measurement function -possibilities of partially automated system control. Z Kardiol. 1998 Aug; 87(8):630-9.

Dürsch M, Pitschner HF, Schwarz T, Sperzel J, König S, Bahavar H, Klövekorn WP, Neuzner J: Therapy with implanted cardioverter-defibrillator: Is a replacement of the impulse generator due to battery depletion also necessary without the occurrence of a tachyarrhythmia episode? Z Kardiol. 1998 Jan; 87(1):32-7.

Sperzel J, Schwarz T, Poschmann U, Ehrlich W, Pitschner HF, Neuzner J.
Herzschrittmacherther Elektrophysiol. 1998 Feb;9 Suppl 1:46-7.

Kostin S, Scholz D, Shimada T, Maeno Y, Mollnau H, Hein S, Schaper J: The internal and external protein scaffold of the T-tubular system in cardiomyocytes. Cell Tissue Res 1998 Dec; 294(3):449-60.

Roth M, Reuthebuch O, Klövekorn WP, Bauer EP: Thrombus formation of the right heart. Eur J Cardiothorac Surg 1998 Feb;13(2):216-7.

Elsässer A, Müller KD, Vogt A, Strasser R, Gagel C, Schlepper M, Klövekorn WP: Assessment of myocardial viability: Dobutamine echocardiography and thallium-201 single-photon emission computed tomographic imaging predict the postoperative improvement of left ventricular function after bypass surgery. Am Heart J 1998 Mar; 135(3):463-75.

1997

Roth M, Bauer EP, Reuthebuch O, Klövekorn WP: Single leukocyte filter (Pall BC1B) fails in multidose cold blood cardioplegia. J Thorac Cardiovasc Surg 1997 Jun; 113(6):1116-7.

Neuzner J, Schwarz T, Strasser R, Schlepper M, Pitschner H: Effect of the addition of an abdominal hot can cardioverter/defibrillator pulse generator on the defibrillation energy requirements in a single-lead endocardial defibrillation system. Eur Heart J. 1997 Oct;18(10):1655-8.

Roth M, Bauer EP, Reuthebuch O, Klövekorn WP: Reoperations after dacron patch aortoplasty with heparinized femoro-femoral bypass. Eur J Cardiothorac Surg 1997 May; 11(5):997-1000.

Bauer EP, Reuthebuch OT, Roth M, Skwara W, Klövekorn WP: Video-assisted resection of hypertrophied and fibrous intraventricular tissue. Ann Thorac Surg 1997 Apr; 63(4):1180-2.

Roth M, Reuthebuch O, Bauer EP, Klövekorn WP: Images in cardio-thoracic surgery. Cardioscopic examination of left ventricular thrombus. Eur J Cardiothorac Surg 1997 Mar; 11(3):573.

Elsässer A, Schlepper M, Klövekorn WP, Cai WJ, Zimmermann R, Müller KD, Strasser R, Kostin S, Gagel C, Münkel B, Schaper W, Schaper J: Hibernating myocardium: an incomplete adaptation to ischemia. Circulation 1997 Nov 4; 96(9):2920-31.

Devaux B, Scholz D, Hirche A, Klövekorn WP, Schaper J: Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur Heart J 1997 Mar; 18(3):470-9.

1996

Hein S, Schaper J. Pathogenesis of dilated cardiomyopathy and heart failure: insights from cell morphology and biology. Curr Opin Cardiol 1996 May; 11(3):293-301. Review.

Neuzner J, Pitschner HF, Schwarz T, Dürsch M, Schlepper M: Effects of electrode polarity on defibrillation thresholds in biphasic endocardial defibrillation. Am J Cardiol. 1996 Jul 1;78(1):96-7.

Schwarz T, Willems R, Kisch K. Clinical performance of a new integrated transvenous defibrillation lead system: Results of a randomized European Multicenter Study. Vortrag in Nizza 1996.

Bauer EP, Reuthebuch OT, Roth M, Klövekorn WP: Diagnostic transaortic cardioscopy of the left ventricle. Ann Thorac Surg 1996 Dec; 62(6):1845-6.

Bauer EP, Schönburg M, Schwarz T, Piepho A, Klövekorn WP: Valve surgery combined with coronary artery operation: is the use of internal mammary artery a predictor for early complications? Eur J Cardiothorac Surg 1996; 10(4):248-52.

Klövekorn WP: Heart surgery in elderly patients. Langenbecks Arch Chir Suppl Kongressbd 1996;113:1009-12.

1995

Hein S, Scheffold T, Schaper J: Ischemia induces early changes to cytoskeletal and contractile proteins in diseased human myocardium. J Thorac Cardiovasc Surg 1995 Jul; 110(1):89-98.

Neuzner J, Götzke J, Schwarz T, Pitschner HF, Schlepper M: VDDR Herzschrittmacher-Therapie bei Patienten nach Katheterablation des AV-Knotens: Akute und chronische Sensingschwell für atriale Tachyarrhythmien. Herzschr Elektrophys 1995 6:17-23.

Schaper J, Hein S, Scholz D, Mollnau H: Multifaceted morphological alterations are present in the failing human heart. J Mol Cell Cardiol 1995 Mar; 27(3):857-61.

Schaper J, Mollnau H, Hein S, Scholz D, Münkel B, Devaux B: Interactions between cardiomyocytes and extracellular matrix in the failing human heart. Z Kardiol 1995; 84 Suppl 4:33-8.

1994

Hein S, Scholz D, Fujitani N, Rennollet H, Brand T, Friedl A, Schaper J: Altered expression of titin and contractile proteins in failing human myocardium. J Mol Cell Cardiol 1994 Oct; 26(10):1291-306.

Sawa Y, Schaper J, Roth M, Nagasawa K, Ballagi G, Bleese N, Schaper W: Platelet-activating factor plays an important role in reperfusion injury in myocardium. Efficacy of platelet-activating factor receptor antagonist (CV-3988) as compared with leukocyte-depleted reperfusion. J Thorac Cardiovasc Surg 1994 Nov; 108(5):953-9.

Bauer EP, Piepho A, Klövekorn WP: Coronary arteriovenous fistula: surgical correction of a rare form. Thorac Cardiovasc Surg 1994 Aug; 42(4):237-9.

Berwing K, Friedl A, Schaper J, Huth C, Schwarz T, Klövekorn WP, Schlepper M: Doppler and echocardiography parameters in detection of acute graft rejection after heart transplantation. Z Kardiol 1994 Mar; 83(3):225-33.